| 通冠薄膜片的辅料选择 |
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| 引用本文： | 郭春燕,刘淑芝,金日显,费虹,王跃生,左桂华. 通冠薄膜片的辅料选择[J]. 中国中医药信息杂志, 2005, 12(3): 55-56,102 |
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| 作者姓名： | 郭春燕 刘淑芝 金日显 费虹 王跃生 左桂华 |
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| 作者单位： | 1. 中国中医研究院中药研究所,北京,100070
2. 辽宁省铁岭市药品检验所,辽宁,铁岭,282326 |
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| 摘 要： | 目的优选并确定通冠薄膜片的辅料。方法采用正交设计法,以片剂的硬度、崩解时限为指标优选辅料配方。结果优选辅料配方:崩解剂、粘合剂为低取代羟丙基甲基纤维素和羧甲基淀粉钠;润滑剂为硬脂酸镁和微粉硅胶;干法制粒。结论通冠薄膜片的辅料组成为(A1 A2)B3C2。
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| 关 键 词： | 通冠薄膜片 辅料 正交实验 |
| 文章编号： | 1005-5304(2005)03-0055-02 |
Selection of Combined Excipients of Tongguan Film Coating Tablet |
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| GUO Chun-yan,LIU Shu-zhi,JIN Ri-xian,et al. Selection of Combined Excipients of Tongguan Film Coating Tablet[J]. Chinese Journal of Information on Traditional Chinese Medicine, 2005, 12(3): 55-56,102 |
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| Authors: | GUO Chun-yan LIU Shu-zhi JIN Ri-xian et al |
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| Abstract: | Objective To optimize the combined excipients formulation of Tongguan tablet. Methods The combined excipients were optimized by using orthogonal design, and taking the hardness and the disintegrating time of tablet as indices. Results The optimized formulation containd that disintegrants and binders were L-Hydroxypropyl Methylcellulose and Sodium carboxymethy starch. Moistening agents was Magnesium Stearate; Granuled method was dry granule. Conclusion Combined excipients formulation of Tongguan tablet was ensured as (A1 A2)B3C2. |
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| Keywords: | Tongguan film coating tablets excipient orthogonal design |
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