尼群地平对缺血再灌注肺脂质过氧化反应的影响

目的探讨肺缺血再灌注损伤的发病机理，观察尼群地平的防治效果。方法７２只大鼠随机分成假手术组、缺血再灌注组和治疗组，采用肺在体温缺血再灌注损伤模型，于缺血４５分钟、再灌注后１小时、２小时、４小时取损伤肺组织测丙二醛（ＭＤＡ）、超氧化物歧化酶（ＳＯＤ）和总钙含量。结果缺血再灌注组各时相肺组织ＭＤＡ含量上升（Ｐ＜０．０５），ＳＯＤ含量显著下降（Ｐ＜０．０５），总钙含量显著升高（Ｐ＜０．０５），尼群地平可减轻肺组织ＭＤＡ和组织总钙含量的升高（Ｐ＜０．０５）。结论钙超载和自由基反应共同参与了肺缺血再灌注损伤，二者可能相互影响，相互促进；尼群地平通过阻滞钙通道，影响自由基系统而对缺血再灌注肺起保护作用

Effects of Nitrendipine on Lipid Peroxidation Following Pulmonary Ischemia reperfusion in Rats

Objective To investigate the possible mechanismes of pulmonary ischemia reperfusion injury,and to observe the preventive and therapeutic effects of nitrendipine on peroxidation following pulmonary ischemia reperfusion. Methods Results In IR group,the contents of MDA increased evidently ( P <0 05),the contents of SOD reduced remarkablely ( P <0.05),and the levels of total calcium increased significantly( P <0 05) during 45 min of ischemia and reperfusion for 4h. In NT group, MDA and total calcium were decreased as compared with IR group( P <0 05, P <0.01),SOD was higher than that in IR group. Conclusion Both calcium overload and free radicals may participate in the lung damage following ischemia reperfusion and be mutually affected and promoted.Nitrendipine can play a protective role by blocking calcium channel and inhabiting free radicals response