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The hereditary spastic paraplegias |
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| Authors: | Evan Reid |
| Affiliation: | (1) Department of Medical Genetics, Cambridge Institute for Medical Research, Wellcome/MRC Building, Addenbrooke’s Hospital, Cambridge CB2 2XY, UK e-mail: ereid@hgmp.mrc.ac.uk, Tel.: +44-1223-336905, Fax: +44-1223-331206, GB |
| Abstract: | The hereditary spastic paraplegias are a complex group of neurodegenerative conditions which are characterised by slowly progressive lower limb spasticity. This article describes the main clinical features of pure and complicated hereditary spastic paraplegias and summarises recent advances in our understanding of the molecular genetics of these conditions. Received: 2 June 1999 Accepted: 7 August 1999 |
| Keywords: | Hereditary spastic paraplegia Molecular genetics Review |
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