CTLA-4 gene polymorphisms and susceptibility to chronic obstructive pulmonary disease |
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| Authors: | Lijing Deng Haixia Zhou Jing Yang Jun Xiao Bo Wang Lan Wang Xuemei Ou Yulin Feng |
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| Affiliation: | 1.Department of Intensive Care Unit, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China;2.Department of Respiratory Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China |
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| Abstract: | ![]()
Objective: The aim of this study was to investigate whether four single nucleotide polymorphisms (SNPs) in CTLA-4 gene are associated with chronic obstructive pulmonary disease (COPD) in a Chinese population. Methods: Samples were collected from a Chinese population and analyzed for the association of SNPs in CTLA-4 gene with COPD in a case-control study. Four SNPs (rs231775, rs3087243, rs231725, rs5742909) in CTLA-4 gene were chosen and genotyped. The results were then analyzed using statistical methods. Results: We found that none of these four SNPs (rs231775, rs3087243, rs231725, rs5742909) in CTLA-4 gene were associated with the disease. Conclusion: Our data suggested that there was no significant association between these four SNPs in CTLA-4 gene and COPD susceptibility in a Chinese population. |
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| Keywords: | CTLA-4 chronic obstructive pulmonary disease polymorphisms |
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