| 2型糖尿病患者外周血单个核细胞中醛糖还原酶mRNA水平与糖尿病肾病危险性的关系 |
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| 引用本文： | 何敏慧,李红,李成江. 2型糖尿病患者外周血单个核细胞中醛糖还原酶mRNA水平与糖尿病肾病危险性的关系[J]. 中华内分泌代谢杂志, 2003, 19(6): 467-469 |
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| 作者姓名： | 何敏慧 李红 李成江 |
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| 作者单位： | 1. 杭州师范学院医学院,310012
2. 310003,杭州,浙江大学附属第一医院内分泌科 |
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| 基金项目： | 浙江省教育厅科研基金资助项目 (982 0 1 3)，浙江省卫生厅科研基金资助项目 (98A0 1 3) |
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| 摘 要： | 以RT-PCR法检测外周血单个核细胞(PBMC)中醛糖还原酶(AR)mRNA水平。2型糖尿病患者的PBMC AR mRNA水平与尿白蛋白排泄率呈正相关，提示AR活性与糖尿病肾病的发病机制有关。
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| 关 键 词： | 2型糖尿病 外周血 单个核细胞 醛糖还原酶 mRNA水平 糖尿病肾病 危险性 尿白蛋白排泄率 |
| 修稿时间： | 2002-05-28 |
Relationship between aldose reductase gene expression in peripheral blood mononuclear cells and the risk of diabetic nephropathy in type 2 diabetic patients |
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| HE Min-hui,LI Hong,LI Cheng-jiang. Relationship between aldose reductase gene expression in peripheral blood mononuclear cells and the risk of diabetic nephropathy in type 2 diabetic patients[J]. Chinese Journal of Endocrinology and Metabolism, 2003, 19(6): 467-469 |
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| Authors: | HE Min-hui LI Hong LI Cheng-jiang |
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| Affiliation: | HE Min-hui,LI Hong,LI Cheng-jiang. Department of Endocrinology,The First Hospital Affiliated to Zhejiang University,Hangzhou 310003 |
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| Abstract: | Aldose reductase (AR) mRNA level in peripheral blood mononuclear cells was assayed by RT-PCR. There was a positive correlation between PBMC AR mRNA level and urinary albumin excretion rate in type 2 diabetic patients. The result suggests that AR activity is related to the pathogenesis of diabetic nephropathy. |
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| Keywords: | Aldose reductase Diabetes mellitus non-insulin dependent Diabetic nephropathies Urinary albumin excretion rate |
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