Duodenal G- and D-cell changes following corticosteroid administration

Summary Prednisolone administration in guinea pigs for 20 days induces significant hypergastrinemia and duodenal G-cell hyperplasia. Hypergastrinemia and duodenal G-cell hyperplasia are less prominent following 40 days of prednisolone administration and this could be partly attributed to the duodenal D-cell increased activity, which represents an adaptive response to the alterations of gastric secretory functions induced by corticosteroids.Abbreviations DAB Diaminobenzydine - D cell Somatostatin-producing cell - G cell Gastrin-producing cell - PAP Peroxidase-antiperoxidase