Effects of sevoflurane on myocardial metabolism during postischemic reperfusion in the rat

In experiments on isolated rat heart lung preparation, the effects of sevoflurane on myocardial metabolism during postischemic reperfusion were evaluated with intramyocardial high energy phosphates, lactate and glycogen. Hearts were perfused for 10min initially and made globally ischemic for 8min. Afterwards, they were reperfused for 12min. Sevoflurane was administered from 5min after the start of perfusion to the end of reperfusion. There was no significant difference in myocardial lactate levels between the sevoflurane (S) and control groups. However, the myocardial ATP level in Group S was significantly higher than that in control (17.45 ± 1.51 vs 15.50 ± 0.87:P < 0.01). The administration of sevoflurane to the isolated rat heart during pre- and post-ischemia enhanced metabolic recovery in the postischemic state.(Kashimoto S, Oguchi T, Kume M et al.: Effects of sevoflurane on myocardial metabolism during postischemic reperfusion in the rat. J Anesth 2: 23–26, 1989)