| 胃泌素及其受体拮抗剂L－365260对BGC－823细胞系细胞微丝作用的研究 |
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| 引用本文： | 高文和,许德新,王俊平,刘萍,黄乃侠,吴琳. 胃泌素及其受体拮抗剂L－365260对BGC－823细胞系细胞微丝作用的研究[J]. 天津医科大学学报, 1996, 0(3) |
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| 作者姓名： | 高文和 许德新 王俊平 刘萍 黄乃侠 吴琳 |
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| 作者单位： | Department of Biology，Department of Medical Sciences |
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| 摘 要： | 细胞表面微绒毛和细胞微丝状态与细胞运动密切相关。在人胃癌ＢＧＣ－８２３细胞系体外培养液中加用胃泌素及其受体拮抗剂，发现经胃泌素作用后的ＢＧＣ－８２３细胞微丝紊乱，细胞表面微绒毛多而密集，经Ｌ－３６５２６０作用后则微丝长而粗，排列规则，表面微绒毛少。提示，胃泌素能增强ＢＧＣ－８２３细胞系的运动，可能有促进肿瘤细胞转移的作用，这种作用可被Ｌ－３６５２６０所拮抗。
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| 关 键 词： | 人BGC－823细胞系；胃泌素；L－365260；微丝 |
THE STUDY OF GASTRIN AND L-365260 ON EFFECTS OF MICROFILAMENTS OF HUMAN GASTRIC CARCINOMA CELL LINE BGC-823 |
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| Gao Wenhe et al. THE STUDY OF GASTRIN AND L-365260 ON EFFECTS OF MICROFILAMENTS OF HUMAN GASTRIC CARCINOMA CELL LINE BGC-823[J]. Journal of Tianjin Medical University, 1996, 0(3) |
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| Authors: | Gao Wenhe et al |
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| Abstract: | The microfilaments(MF)of human gastric Cancer cell line BGC-823 Were observed by using Coomassie Brilliant Blue R250 Staining and electron microscope.It was found that the MF of BGC-823 cell line had decreased after the treatment of gastrin and this effect could be inhibited by L-365260.These Cytoskeleton changes might be related to the biological characteristics and the metastasis and invastion of the tumor cells. |
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| Keywords: | Human gastric cgarcinoma cell line BGC-823 Gastrin L-365260 Microfilaments. |
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