|
|||||
|
|
Human calcitonin has the same inhibitory effect on osteoclastic bone resorption by human giant cell tumor cells as salmon calcitonin |
|
| Authors: | S Lida S Kakudo Y Mori M Matsui K Magota Y Kitajima N Nakamura H Mano Y Hakeda H Azuma T Kurokawa M Kumegawa |
| Institution: | (1) Department of Orthopedic Surgery, Saitama Medical School, 350-04 Moroyama, Saitama;(2) Department of Oral Anatomy, Meikai University Dental School, 350-02 Sakado, Saitama;(3) Department of Orthopedic Surgery, Tokyo University Medical School, 113 Hongo, Tokyo;(4) Suntory Institute for Biomedical Research, 618 Mishima, Osaka;(5) Department of Orthopedic Surgery, Osaka University Medical School, 618 Osaka, Japan |
| Abstract: | Human calcitonin (hCT) has been reported to have a less hypocalcemizing effect on rats and to have a lower binding affinity for the receptor of mouse osteoclasts than salmon CT(sCT). In this study we comparatively examined the effect of hCT and sCT on osteoclastic boneresorbing activity of unfractionated cells obtained from human giant cell tumor of bone and from rabbit and mouse long bones. We found that hCT had the same inhibitory effect as sCT on the bone-resorbing activity of human and rabbit osteoclastic cells, but a different one on that of mouse cells. These results indicate that the activity of drugs should be assayed using human cells if possible. |
| Keywords: | Human calcitonin Pit assay Human os-teoclasts Inhibition bone Resorption |
| 本文献已被 SpringerLink 等数据库收录！ | |