美沙酮片对慢性癌痛病人镇痛效果临床评价

目的··:观察美沙酮片对慢性癌痛患者的镇痛效果及不良反应。方法··:采用多中心自身对照试验和无对照开放试验设计。用疼痛强度 ,疼痛强度差 ,疼痛缓解度 ,中度以上疼痛缓解率作为镇痛评价指标。结果·· :口服美沙酮10 -15mg,每天2次 ,即可明显或完全缓解疼痛。主要不良反应有头晕、嗜睡、恶心、便秘、排尿困难等。结论··:美沙酮可有效控制慢性癌痛 ,镇痛效果与硫酸吗啡缓释片相当。不良反应也与硫酸吗啡缓释片类似。

CLINICAL EVALUATION OFANALGESIC EFFECT OF METHADONE TABLETS ON CHRONIC CANCER PAIN

Objective: To evaluate the analgesic efficacy and safety of methadone tablets in the treatment of chronic severe cancer pain. Method: An open,crossover study to compare methadone with sustained-release oral morphine was carried out in 28 patients. Another 85 patients were recruited into an open study. Result: Pain could be controlled completely or obviously by oral methadone tablets 10-15 mg,twice a day. Main adverse drug reactions were dizziness, drowsiness, nausea, constipation and dysuresia. Conclusion:Pain can be well relieved by methadone throughout the study, with similar adverse drug reactions of sustained-release morphine.