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| 人乳头瘤病毒治疗性疫苗研究进展 | |
| 引用本文： | Liu B,Zhao QZ. 人乳头瘤病毒治疗性疫苗研究进展[J]. 中国医学科学院学报, 2007, 29(5): 685-690 |
| 作者姓名： | Liu B Zhao QZ |
| 作者单位： | 中国医学科学院,北京协和医学院,肿瘤研究所细胞生物学与分子生物学研究室,北京,100021 |
| 基金项目： | 国家高技术研究发展计划(863计划);国家自然科学基金 |
| 摘 要： | 人乳头瘤病毒(HPV)感染引起的疾病流行广泛,但现有治疗手段有限。尽管HPV预防性疫苗即将在世界范围内推广,但从中受益还需数十年时间,而且对于已感染HPV且出现病变的患者,预防性疫苗作用不大。HPV治疗性疫苗主要是针对已感染HPV的患者,其类型有病毒/细菌载体疫苗、肽疫苗、蛋白疫苗、DNA疫苗、细胞疫苗等。 |
| 关 键 词： | 人乳头瘤病毒 疫苗 治疗 |
| 文章编号： | 1000-503X（2007）05-0685-06 |
| 修稿时间： | 2007-04-29 |
Advances in human papillomavirus therapeutic vaccine |
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| Liu Bo,Zhao Qing-zheng. Advances in human papillomavirus therapeutic vaccine[J]. Acta Academiae Medicinae Sinicae, 2007, 29(5): 685-690 | |
| Authors: | Liu Bo Zhao Qing-zheng |
| Affiliation: | Department of Cellular and Molecular Biology, Cancer Institute, CAMS and PUMC, Beijing 100021, China |
| Abstract: | Human papillomavirus(HPV) infection is very common but with limited therapies available.Although the prophylactic vaccination will be promoted worldwide soon,it can only show its benefits decades later.For individuals who already have established infections and dysplasias,it has little efficacy.In contrast,the therapeutic vaccines bridge the temporal deficit by fighting against the established HPV infections and HPV-related diseases.HPV oncogenes may be delivered in viral and bacterial vectors,in peptides or protein,in nucleic acid form,or in cell-based vaccines.This review summarizes the clinical trials of HPV therapeutic vaccines under the way and the different preclinical research strategies that are under investigations. |
| Keywords: | human papillomavirus vaccine therapy |
| 本文献已被 CNKI 维普 万方数据 PubMed 等数据库收录！ | |