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| 置换肽对豚鼠银屑病样模型血清IFN-γ的抑制作用 | |
| 引用本文： | 史晓蔚,沈柱,王刚,李红,刘玉峰. 置换肽对豚鼠银屑病样模型血清IFN-γ的抑制作用[J]. 中国皮肤性病学杂志, 2008, 22(12) |
| 作者姓名： | 史晓蔚 沈柱 王刚 李红 刘玉峰 |
| 作者单位： | 第四军医大学西京医院全军皮肤病研究所,陕西,西安,710032 |
| 摘 要： | 目的探讨置换肽(APL)对豚鼠银屑病样模型血清IFN-γ浓度的影响。方法采用心得安法制备豚鼠耳廓银屑病样模型,APL组和对照组皮损处分别外涂APL及对照药物,ELISA法检测血清IFN-γ变化,分析涂药前、后各组内及组间的差异。结果APL组动物血清IFN-γ表达量明显低于对照组(P<0.05),高浓度的APL对IFN-γ的抑制作用更强。结论提示APL对豚鼠银屑病样模型血清IFN-γ的表达具有抑制作用。 |
| 关 键 词： | 置换肽 IFN-γ 银屑病 动物模型 |
Depressant Effect of APL on IFN-γ of Psoriasis-like Model of Guinea pig |
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| SHI Xiao-wei,SHEN Zhu,WANG Gang,et al. Depressant Effect of APL on IFN-γ of Psoriasis-like Model of Guinea pig[J]. The Chinese Journal of Dermatovenereology, 2008, 22(12) | |
| Authors: | SHI Xiao-wei SHEN Zhu WANG Gang et al |
| Abstract: | Objective To investigate the effect of APL on IFN-γ of psoriasis-like model of guinea pig.Methods Propranolol was applied to make the psoriasis-like model of guinea pig.We topically applied APL and control medicines on the ears of guinea pig and detected the expression of IFN-γ by ELISA method.We analyzed the variability of the concentration of IFN-γ in groups before and after using medicines.Results The expression of IFN-γ of guinea pig in APL groups was lower than that of the controls(P<0.05).The higher concentration of APL could suppress IFN-γ more.Conclusion It suggested that APL had the depressant effect on psoriasis-like model of guinea pig. |
| Keywords: | APL IFN-γ Psoriasis Animal model |
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