抗凝药物对突发性聋疗效的观察

目的 探讨不同抗凝药物的降粘效应对突发性聋（突聋）的疗效。方法 对160例突聋患者随机分为四组，分别采用力源溶栓酶（A组）、蝮蛇抗栓酶（B组）、尿激酶（C组）、低分子右旋酐加丹参（D组）治疗，互为平等对照。结果 各组间总有效率无显著性差异（P＞0.05），但A组与B、C、D各组显效率＋疮愈率比较有显著性差异（P＜0.05）。经血液流变学检查87例为高血粘滞症（54.4%，87／160），对其中血纤维蛋白原值＞400mg/dl患者79例疗效观察显示：A组总有效率为84.2%、B组为67.2％、C组为64.7%、D组为68.6%，A组疗效明显优于B、C、D各组。结论 对早期突聋患者采用不同抗凝药物治疗，其听力改善程度是有差别的。力源溶栓酶为治疗伴有高血粘滞症突聋患者的有效药物，早期使用，可提高疗效。

The Effect of Anticoagulant Drugs in Sudden Deafness

Objective To determine the effect of various anticaoagulant drugs by decrease in viscosity to treat the sudden deafness. Methods 160 cases with sudden deafnss were treated respectively by making use of Liyuan streptase(group A), Snake venom antithromous enzyme (group B), Urokinase(group C), Dextranum 40 plus Saluiae Miltiorrhiza( group D) as parallel con- trol. Results Total effective rates in four groups didn't show significant difference( P >0.05), but the obvious effective rate and curative rate in Group A were more remarkable compared with group B, C, D (P > 0.05). 87 cases were confirmed to be hyper- viscosity by hemorrheology (54.5% ,87/160). Conclusion Patients with sudden deafness should be treated by the use of antico- agulant drugs. Liyuan streptase is effective to treat sudden deafness associated with hyperviscosity. It should be used early to improve effective rate.