胃乐冲剂对大鼠慢性萎缩性胃炎的实验研究

目的:研究胃乐冲剂对大鼠慢性萎缩性胃炎的作用与机制。方法:以2%的水杨酸钠和30%的酒精的混合溶液对大鼠进行灌胃复制慢性萎缩性胃炎大鼠。测定胃液酸度、胃蛋白酶活性和血中胃泌素、cAMP、cGMP含量;并观察对小鼠胃肠推进功能的影响和抗炎镇痛作用。结果:胃乐冲剂明显增加游离酸、总酸度、胃蛋白酶活性,降低PH值,增加cAMP含量,降低cGMP、胃泌素含量;可加快小鼠小肠推进速度,并有一定的抗炎镇痛作用。结论:胃乐冲剂能明显改善模型大鼠的胃内环境,增强消化功能、有明显的保护胃粘膜作用,并可增强胃肠功能,有一定的抗炎镇痛作用。

Experimental Study of Weile Granules on Chronic Atrophic Gastritis in Rats

Objective:To research the therapeutic action and its mechanism of Weile Granules on Chronic Atrophic Gastritis.Methods:We established Chronic Atrophic Gastritis model by giving rats with the mixed solution which consisted of 2% sodium salicylate and 30% alcohol by means of intragastric administration.We detected free acidity,total acidity and Pepsin activity of Gastric juice and cAMP,cGMP and Gastrin in plasma.The effect on small intestinal propulsion ability in mouse and the function of anti-inflammatory and analgesia was studied.Results:Weile Granules could significantly raise the free acidity and total acidity of Gastric juice and enhance the Pepsin activity,and could raise the contents of cAMP and reduce the contents of cGMP and Gastrin in plasma.Weile Granules also could increase the function of peristalsis for small intestine and had the function of anti-inflammatory and analgesia.Conclusion:Weile Granules could improve the intragastric environment of Chronic Atrophic Gastritis,and enchance digestive function.It could enchance the function of peristalsis for small intestine,and might have the function of anti-inflammatory and analgesia.