三叶委陵菜乙醇提取物镇痛作用的研究

目的研究三叶委陵菜乙醇提取物的镇痛作用.方法热板法和扭体法.结果热板法中,灌胃三叶委陵菜乙醇提取物(0.5 g/kg,1.25g/kg,2.5g/kg)15,30,60和90min后,小鼠的痛阈均明显延长,其中灌胃2.5g/kg提取物90min后的镇痛效应比氨基比林(100 mg/kg i.m.)的好.在对非甾体药敏感的扭体法中,不同剂量的三叶委陵菜醇提物(0.5 g/kg,1.25g/kg,2.5g/kg o.p.)均能显著抑制0.7%醋酸引起的扭体反应.结论三叶委陵菜具有镇痛效应,民间用三叶委陵菜医治牙痛及其它疼痛症的疗效得到了验证.

STUDIES OF ANALGESIC PROPERTIES OF ETHANOLIC EXTRACT FROM POTENTILLA FRENIANA BORNM.VAR.SINICA MIGO

Objective:To evaluate the analgesic effect from the ethanolic extract of Potentilla freyniana Bornm. var. Sinica Migo (PBSM).Methods:The analgesic properties of PBSM were investigated by the classical hot plate test and the writhing test.Results:In the hot plate test,the ethanolic extract of PBSM(0.5g/kg,1.25 g/kg,2.5g/kg,o.p.) significantly delayed the response time to hot-plate thermal stimulation 15,30,60 and 90 min after treatment,and 90 min after treatment,the effect of PBSM (2.5g/kg) was higher than that of aminopyrine (100 mg/kg i.m.).In the writhing test, which is more sensitive for non-steroidal analgesics, the ethanolic extract of PBSM (0.5g/kg,1.25g/kg,2.5g/kg o.p.) dose significantly inhibited the writhes induced by 0.7% acetic acid.Conclusion:Potentilla freyniana Bornm.var.Sinica Migo may have analgesic activity and affirm the claim by traditional medicine practitioners of the use in toothache or some painful conditions.