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| 糖尿病大鼠心力衰竭时心肌细胞凋亡的研究 | |
| 引用本文： | 符丽娟,庞东渤,王洪新. 糖尿病大鼠心力衰竭时心肌细胞凋亡的研究[J]. 中西医结合心脑血管病杂志, 2005, 3(3): 236-237 |
| 作者姓名： | 符丽娟 庞东渤 王洪新 |
| 作者单位： | 辽宁省锦州医学院 |
| 摘 要： | 目的探讨糖尿病大鼠心力衰竭时是否存在心肌细胞凋亡.方法建立STZ糖尿病大鼠模型,饲养12周,经心功能检测后确认为糖尿病心力衰竭的大鼠,采用TUNEL法及TEM法,检测糖尿病大鼠左室心肌的凋亡细胞.结果 糖尿病大鼠出现心功能异常并可见凋亡的心肌细胞,而对照组左室心肌组织中未见心肌细胞凋亡.结论心肌细胞凋亡与糖尿病大鼠心力衰竭密切相关. |
| 关 键 词： | 糖尿病 心力衰竭 心肌细胞凋亡 |
| 文章编号： | 1672-1349(2005)03-0236-02 |
| 修稿时间： | 2004-10-08 |
Study on Cardiac Myocyte Apoptosis in Diabetic Rats with Heart Failure |
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| Fu Lijuan,Pang Dongbo,Wang Hongxin. Study on Cardiac Myocyte Apoptosis in Diabetic Rats with Heart Failure[J]. Chinese Journal of Integrative Medicine on Cardio-/Cerebrovascular Disease, 2005, 3(3): 236-237 | |
| Authors: | Fu Lijuan Pang Dongbo Wang Hongxin |
| Affiliation: | Jinzhou 121001 |
| Abstract: | Objective To explore whether Apoptosis exists in diabetic rats with heart failure.Methods Diabetic animal models were induced by streptozotocin on SD rats.After 12 weeks,the rats with heart failure were confirmed by heart function detection.The myocardial apoptosis in left ventricle were detected by TdT-mediated dUTP nick end labeling(TUNEL) and transmission electron microscope.Results Diabetic rats exhibited abnormal heart function at 12 week, and myocardial apoptosis were identified in left ventricle,there was no apoptosis in control group.Conclusion Myocardial apoptosis is associated with diabetic rats with heart failure. |
| Keywords: | diabetes heart failure cardiac myocyte apoptosis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |