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Heredity in multiple system atrophy |
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| Authors: | Soma Hiroyuki Yabe Ichiro Takei Asako Fujiki Naoto Yanagihara Tetsuro Sasaki Hidenao |
| Affiliation: | aDepartment of Neurology, Hokkaido University, Graduate School of Medicine, N15W7. Kita-Ku, Sapporo, Hokkaido, 060-8368, Japan bHokuyukai Neurology Hospital, Sapporo, Hokkaido, Japan cDepartment of Neurology, Sapporo Minami National Hospital, Sapporo, Hokkaido, Japan dDepartment of Neurology, Ebetsu City Hospital, Ebetsu, Hokkaido, Japan |
| Abstract: | We investigated the family histories of 157 Japanese patients with probable or possible multiple system atrophy (MSA). A family history of neurodegenerative disorders was only detected in three MSA patients (1.9%). We evaluated these patients by careful neurological examination, neuroimaging studies, and genetic studies to exclude hereditary spinocerebellar ataxia with a similar clinical phenotype to MSA. The results indicated that one of them had a family history of MSA. Although the familial presence of neurodegenerative disorders is rare in MSA patients, the existence of such cases suggests that MSA may have a genetic background. |
| Keywords: | Multiple system atrophy Family history Multigenic aetiology Spinocerebellar ataxia Parkinsonism Neurodegenerative disorders |
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