化放疗序贯治疗局部晚期非小细胞肺癌疗效观察

目的探讨局部晚期非小细胞肺癌的有效治疗方案.方法 105例局部晚期非小细胞肺癌随机分为化、放序贯治疗组(A组)与单纯放疗组(B组).A组采用MVP或NP方案全身化疗2周期,休息1至2周胸部放疗;B组不做化疗,胸部放疗同A组.观察近期疗效,生存期,1、2年生存率及主要毒副反应、并发症.结果 A组有效率高于B组(92.0%对65.5%),中位生存期A组长于B组(15.5个月对11.4个月),A组和B组1,2年生存率分别为68.0%、39.5%和60.0%、17.5%.2年生存率差异有显著性(χ2=4.65,P＜0.05).两组在Ⅲ～Ⅳ级血液学毒性、放射性食管炎、放射性肺炎发生率方面差异无显著性(P＞0.05).结论序贯化、放疗可提高局部晚期非小细胞肺癌局部控制率,延长生存期,毒副反应可以耐受,不增加并发症.

Observation on efficacy of radiotherapy following chemotherapy in treatment of local advanced non-small cell lung caner

Objective To explore the effective regimen for treatment of local advanced non-small cell lung cancer. Methods 105 patients with local advanced NSCLC were randomly divided into two groups: radiotherapy following chemotherapy group(group A) and radiotherapy alone group (group B) . Group A used chemotherapy of MVP or NP regimen for 2 cycles and then received chest radiotherapy after resting for 1-2 weeks. In group B,chemotherapy was not gjven and chest radiotherapy was same as for group A.The short-term therapeutic efficacy, survival time, 1-and 2-year survival rates,important toxicity and complications were observed. Results The remission rate in group A was higher than that in group B(92.0% vs65.5%) ,and the median survival time in group A was longer than that in group B(15.5 months vs 11.4 months). 1-and 2-year survival rates were 68.0% ,39.5% and 60.0%, 17.5%, respectively. The 2-year survival rates had significant difference (x2 =4.65, P < 0.05) .There was no difference in the rates of hematological toxicity of degree 3-4, radioactive esophageal infection and radioactive lung infection between the two groups( P > 0.05) . Conclusions Radiotherapy following chemotherapy elevated the local control rate of NSCLC and prolonged survival time as well.The toxicity was tolerable, and complication did not increase.