Effect of resistive discontinuities on waveshape and velocity in a single cardiac fibre |
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Authors: | Mr C S Henriquez R Plonsey |
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Institution: | (1) Department of Biomedical Engineering, Duke University, 27706 Durham, NC, USA |
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Abstract: | A computer model of a one-dimensional cardiac fibre of resistively coupled cells is used to investigate the influence of the
junction resistance on the nature of conduction. The results of the simulations are presented and indicate that the effect
of the junction on both intracellular and extracellular waveshape and on the velocity of propagation depends on the size and
frequency of the coupling resistance and the kinetics of the active membrane. Significant changes in these factors are not
observed without the generation of prepotentials in the action potential upstroke. The absence of this ‘signature’ in microelectrode
recordings of activity in ventricular muscle suggests that under normal conditions cardiac tissue behaves as a functional
syncytium. |
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Keywords: | Cardiac electrophysiology Discontinuous propagation Ebihara and Johnson model Gap junction Propagation models |
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