消痞通络方干预糖尿病胃轻瘫(寒热错杂证)临床及机制研究

目的观察消痞通络方干预糖尿病胃轻瘫(寒热错杂证)的临床疗效,探讨其作用机制。方法选取2018年7月—2019年3月该院收治的70例糖尿病胃轻瘫患者,随机分为实验组和对照组,前者给予中药消痞通络方联合枸橼酸莫沙必利片治疗,后者给予枸橼酸莫沙必利片治疗,每组各35例。观察治疗前后各组中医证候积分、胃排空、胃泌素、胃动素的指标变化。结果实验组有效率91.4%,对照组有效率85.7%,差异有统计学意义(P<0.05);治疗前后两组中医证候积分、胃动素、胃泌素组内和组间对比,差异有统计学意义(P<0.05)。结论消痞通络方能够改善糖尿病胃轻瘫(寒热错杂证)临床症状,促进胃排空,作用机制与调节胃动素、胃泌素有关。

Clinical and Mechanism Study of Xiaopitongluo Recipe on Intervention of Diabetic Gastroparesis(Cold Fever and Miscellaneous Syndrome)

Objective To observe the clinical efficacy of Xiaopitongluo Recipe in intervention of diabetic gastroparesis(cold fever and miscellaneous syndrome)and to explore its mechanism.Methods Seventy patients with diabetic gastroparesis admitted to the hospital from July 2018 to March 2019 were randomly divided into experimental group and control group.The former was given Chinese medicine Xiaopitongluo combined with mosapride citrate tablets,and the latter was treated with mosapride citrate tablets.Each group has 35 cases.The changes of TCM syndrome scores,gastric emptying,gastrin and motilin were observed before and after treatment.Results The effective rate of the experimental group was 91.4%,and the effective rate of the control group was 85.7%.The difference was statistically significant(P<0.05).The difference between TCM syndrome scores,motilin,gastrin group and group between the two groups before and after treatment,statistically significant(P<0.05).Conclusion Xiaopitongluo Recipe can improve the clinical symptoms of diabetic gastroparesis(cold fever and miscellaneous syndrome)and promote gastric emptying.The mechanism of action is related to the regulation of motilin and gastrin.