中性粒细胞与淋巴细胞比值与2型糖尿病肾病进展的相关性

目的探讨中性粒细胞与淋巴细胞比值与2型糖尿病肾病进展的相关性。方法2014年9月—2016年12月间采用回顾性队列研究纳入2型糖尿病患者492例,据24 h尿蛋白总量将492例2型糖尿病患者分为糖尿病无肾病组(DM组)424例,糖尿病肾病组(DN组)68例。收集其临床资料,追踪其3年后DN进展情况。将基线中性粒细胞与淋巴细胞比值(NLR)水平按四分位法分为四组,即最低四分位数组(I组)≤1.37、第二四分位数组(II组)1.38~1.83、第三四分位数组(III组)1.84~2.21、最高4分位数组(IV组)≥2.22。按DN是否进展,将研究对象分为进展组(A组)和未进展组(B组),比较两组基线资料,采用二元Logistic回归,评估糖尿病病程、SBP、HbA1c、BMI及基线NLR水平与DN进展之间的相关性。结果3年后,64例(13.00%)患者糖尿病肾病进展,其中新发糖尿病肾病42例(8.53%)。单因素分析中,A组与B组相比较,年龄、病程、BMI、收缩压、NLR、FPG、HbA1c、TC、TG差异有统计学意义(P<0.05)。结论NLR水平>1.83是T2DM患者DN进展的独立危险因素。

Correlation between Neutrophil to Lymphocyte Ratio and Progression of Type 2 Diabetic Nephropathy

Objective To investigate the correlation between the ratio of neutrophils and lymphocytes and the progression of type 2 diabetic nephropathy.Methods From September 2014 to December 2016 a retrospective cohort study was used to enroll 492 patients with type 2 diabetes.According to the total amount of 24 hours urine protein,492 patients with type 2 diabetes were divided into diabetic nephropathy group(DM group)424 and diabetic nephropathy group(DN group)68 patients.Collect clinical data and track the progress of DN after 3 years.The baseline neutrophil-lymphocyte ratio(NLR)levels were divided into four groups according to the quartile,that is,the lowest quartile array(group I)≤1.37,and the second quartile array(group II)1.38 to 1.83;the third fourth quartile array(Group III)1.84 to 2.21,the highest quartile array(Group IV)≥2.22.According to whether DN progressed,the study subjects were divided into progress group(group A)and non-progressive group(group B).Baseline data of the two groups were compared,and binary logistic regression was used to evaluate the duration of diabetes,SBP,HbA1c,BMI,and baseline NLR levels,correlation with DN progress.Results After 3 years,diabetic nephropathy progressed in 64 patients(13.00%),including 42 newly diagnosed diabetic nephropathy(8.53%).In univariate analysis,there were significant differences in age,disease duration,BMI,systolic blood pressure,NLR,FPG,HbA1c,TC,and TG in group A compared with group B(P<0.05).Conclusion NLR level>1.83 is an independent risk factor for DN progression in patients with T2DM.