| 结直肠癌中ERCC1蛋白的表达与预后生存关系的Meta分析 |
| |
| 引用本文： | 来代莉,李金明,崔龙. 结直肠癌中ERCC1蛋白的表达与预后生存关系的Meta分析[J]. 结直肠肛门外科, 2012, 18(3): 162-165 |
| |
| 作者姓名： | 来代莉 李金明 崔龙 |
| |
| 作者单位： | 上海交通大学附属新华医院结直肠肛门疾病外科 |
| |
| 摘 要： | 目的评价结直肠癌患者中核苷酸切除修复交叉互补酶1(ERCC1)蛋白的表达与患者预后的相关性进行meta分析。方法采用计算机检索,检索范围包括全文数据库(CNKI),万方数据库,PubMed、Embase和ASCO数据库。收集比较不同核苷酸切除修复交叉互补酶1蛋白表达水平的结直肠癌患者预后相关的文章,采用revman软件,对文献进行Meta分析。结果最终纳入5项研究,对纳入的文献进行异质性检验显示P=0.14,异质性不大,ERCC1蛋白阴性表达的患者的死亡率低于ERCC1阳性的患者,合并相对危险比RR=0.56;95%可信区间0.37～0.86。结论结直肠癌中ERCC1蛋白阴性的患者预后较ERCC1阳性者好。
|
| 关 键 词： | ERCC1 结直肠癌 Meta分析 预后 |
ERCC1 expression and its prognosis implication in colorectal cancer:a meta-analysis |
| |
| Lai Daili,Li Jinming,Cui Long. ERCC1 expression and its prognosis implication in colorectal cancer:a meta-analysis[J]. Journal of Colorectal & Anal Surgery, 2012, 18(3): 162-165 |
| |
| Authors: | Lai Daili Li Jinming Cui Long |
| |
| Affiliation: | .(Department of Colorectal Surgery,Xinhua Hospital affiliated to Shanghai JiaoTong University School of Medicine,Shanghai,China ;200092) |
| |
| Abstract: | Objective To evaluate the relationship between ERCC1protein expression and its prognostic implication in colorectal caner patients.Methods All the data dealing with the relationship between ERCC1expression and the prognosis of colorectal cancer was researched from PubMed,Embase,ASCO,CNKI and WANFANG.Database.Meta-analysis was conducted by the Stata software.Results We finally identified 5studies.The test for heterogeneity showed that all eligible studies were with no clear heterogeneity(P =0.08).The relative risk(RR) was 0.765,with 95% confidence interval of 0.62～0.95.Conclusion Compared to patients with negative ERCC1protein expression,the patient with positive ERCC1protein expression in colorectal cancer showed poor prognosis. |
| |
| Keywords: | Colorectal cancer ERCC1 Prognosis Meta analysis |
| 本文献已被 CNKI 等数据库收录！ |
|
