碱性成纤维细胞生长因子与肺纤维化

碱性成纤维细胞生长因子(basic fibroblast growth factor,bFGF)是一种重要的多肽生长因子,也是成纤维细胞因子(fibroblast growth factor,FGF)家族原型成员之一.随着对细胞因子在特发性肺纤维化(idiopathic pulmonary fibrosis,IPF)发病中作用认识的逐渐深入,近年研究发现bFGF在纤维化的肺组织、血清、肺泡灌洗液中有高表达并与肺纤维化程度呈正相关,这提示bFGF表达上调与肺纤维化关系密切,抑制促纤维化的细胞因子为IPF的治疗提供了一条新的有效途径[1].

Basic fibroblast growth factor and pulmonary fibrosis

Basic fibroblast growth factor(bFGF)is a significant polypeptide growth factor and one of prototype members in FGF family.With more knowledge about idiopathic pulmonary fibrosis(IPF),it has been discovered that bFGF is high expressed in the lung tissue,serum bronchoalveolar lavage fluid of fibrotic lung'and bFGF is positive correlated with the degree of pulmonary fibrosis.A new effective treatment in IPF can be developed by inhibiting those cytokines of promoting fibrosis.