超声造影在乳腺叶状肿瘤与纤维腺瘤鉴别诊断中的价值

目的探讨超声造影在乳腺叶状肿瘤与纤维腺瘤鉴别诊断中的应用价值。 方法选取我院病理诊断明确且术前进行过超声造影检查的患者（叶状肿瘤23例、纤维腺瘤57例），回顾性分析其超声造影表现，采用χ²检验或t检验分析乳腺叶状肿瘤与纤维腺瘤在超声造影表现和病理中微血管密度间的关系。 结果乳腺叶状肿瘤与纤维腺瘤比较，边界是否清晰，差异无统计学意义（P>0.05），而增强顺序、增强强度、均匀性三者比较，差异均有统计学意义（χ²=22.960、24.419、4.901，P均<0.05）。叶状肿瘤的超声造影表现为增强后边界清晰、散在的离心性不均匀低增强。纤维腺瘤超声造影表现为增强后边界清楚、向心性均匀高增强。 结论超声造影对乳腺叶状肿瘤与纤维腺瘤有一定的鉴别诊断价值，可为临床手术方法的选择提供参考。

Value of contrast-enhanced ultrasound in differential diagnosis of breast phyllodes tumor and fibroadenoma

Objective To assess the value of contrast-enhanced ultrasound in the differential diagnosis of breast phyllodes tumor and fibroadenoma.Methods A retrospective analysis of contrast-enhanced ultrasound findings was performed on patients who were pathologically diagnosed with phyllodes tumor(23 cases)or fibroadenoma(57 cases).The differences between breast phyllodes tumors and fibroadenoma in contrast-enhanced ultrasound findings and pathological microvessel density were analyzed by the Chi-square test or t-test.Results There was no statistically signi ficant di fference(P>0.05)in boundary,but there were statistically significant differences in the sequence,degree,and evenness of contrast enhancement between breast phyllodes tumor and fibroadenoma(χ^2=22.960,24.419,4.901,all P<0.05).The contrast-enhanced ultrasound findings of breast phyllodes tumor were characterized by a clear boundary and peripheral heterogeneous low enhancement.The contrast-enhanced ultrasound findings of fibroadenoma were characterized by a clear boundary and central homogeneous high enhancement.Conclusion Contrast-enhanced ultrasound has appreciated value in the differential diagnosis of breast phyllodes tumor and fibroadenoma,and can provide a reference for the selection of surgical methods.