女性早期胃癌患者淋巴结转移的危险因素分析

目的分析影响女性早期胃癌患者淋巴结转移的危险因素。 方法收集2010年8月至2018年12月南京大学医学院附属鼓楼医院136例女性早期胃癌患者的临床病理资料，单因素分析和多因素Logistic回归分析筛选影响淋巴结转移的危险因素。 结果28例（20.59%）发生淋巴结转移。年龄、是否绝经、Lauren分型和浸润深度与女性早期胃癌患者淋巴结转移有关（P<0.05）。多因素分析显示，是否绝经（P=0.028，OR=2.998，95% CI：1.128~7.966）、肿瘤浸润深度（P=0.015，OR=3.730，95% CI：1.289~10.787）是女性早期胃癌患者发生淋巴结转移的危险因素。 结论女性早期胃癌淋巴转移率为20.59%，未绝经女性更易发生淋巴结转移。是否绝经及肿瘤浸润深度是女性早期胃癌发生淋巴结转移的危险因素。

Risk factors of lymph node metastasis in female early gastric cancer

Objective To investigate the risk factors of lymph node metastasis in female patients with early gastric carcinoma.Methods The clinicopathological data of one hundred and thirty-six female patients with early gastric cancer from August 2010 to December 2018 in Nanjing Drum Tower Hospital were collected retrospectively.The risk factors of lymph node metastasis were screened by single factor analysis and Logistic regression analysis.Results Lymph node metastasis occurred in 28 cases(20.59%),which was related to age,menopause,lauren type,and depth of invasion(P<0.05).Multivariate analysis showed that menopause(P=0.028,OR=2.998,95%CI:1.128-7.966)and tumor infiltration depth(P=0.015,OR=3.730,95%CI:1.289-10.787)were the risk factors of lymph node metastasis in female patients with early gastric cancer.Conclusions The rate of lymph node metastasis is 20.59%in female patients.Premenopausal patients are more likely to have lymph node metastasis.Whether menopause or not and depth of invasion are independent risk factors of lymph node metastasis in female patients with early gastric cancer.