海南省三亚市158例耐多药肺结核患者危险因素的Logistic回归分析

目的 探讨三亚市158例耐多药结核病（MDR-TB）患者的危险因素,为MDR-TB的防治提供科学依据。 方法 对三亚市158例MDR-TB患者（病例组）和316例敏感性结核患者（对照组）的相关情况进行调查,应用单因素及多因素Logistic回归模型分析MDR-TB发生的危险因素。 结果 单因素及多因素Logistic回归分析显示,居住地（OR=2.308,95%CI：1.597~5.104）、既往抗结核治疗史（OR=16.218,95%CI：14.815~25.106）、结核空洞（OR=2.904,95%CI：2.116~7.915）、治疗过程中断（OR=5.706,95%CI：4.508~12.319）、抗结核药物不良反应（OR=3.382,95%CI：2.672~10.137）、不规律用药（OR=2.508,95%CI：1.813~5.646）及首次抗结核治疗效果（OR=3.513,95%CI：2.914~10.870）是MDR-TB发生的危险因素。 结论 三亚市MDR-TB发生的危险因素较多,需要进一步加强早期发现和规范诊疗,以减少MDR-TB的发生。

Logistic regression analysis of risk factors of 158 MDR-TB patients in Sanya,Hainan

Objective To investigate the risk factors of 158 patients with multi-drug resistant tuberculosis (MDR-TB) in Sanya, and we provide scientific basis for the prevention and treatment of MDR-TB. Methods The correlation between 158 MDR-TB patients (case group) and 316 sensitive TB patients (control group) in Sanya was investigated by single-factor and multivariate logistic regression. Univariate and multivariate Logistic regression were used to analyze the risk factors of MDR-TB. Results Univariate and multivariate Logistic regression analysis showed that residence (OR=2.308, 95%CI: 1.597-5.104), previous anti-tuberculosis treatment history (OR=16.218, 95%CI: 14.815-25.106), tuberculosis cavity (OR=2.904, 95%CI: 2.116-7.915), discontinuation of treatment (OR=5.706, 95%CI: 4.508-12.319), adverse reactions to antituberculosis drugs (OR=3.382, 95%CI: 2.672-10.137), irregular drug use (OR=2.508, 95%CI: 1.813-5.646) and first antituberculosis therapeutic effect (OR=3.513, 95%CI: 2.914-10.870) were risk factors for MDR-TB. Conclusion There are many risk factors for the occurrence of MDR-TB in Sanya, and early detection, standardized diagnosis and treatment need to be further strengthened to reduce the occurrence of MDR-TB.