首页 | 本学科首页   官方微博 | 高级检索  
     


Effectiveness of teicoplanin versus vancomycin lock therapy in the treatment of port-related coagulase-negative staphylococci bacteraemia: a prospective case-series analysis
Authors:J.L. Del Pozo, M. Garcí  a Cenoz, S. Hern  ez, A. Martí  nez, A. Serrera, A. Aguinaga, M. Alonso,J. Leiva
Affiliation:aDivision of Infectious Diseases, Clínica Universidad de Navarra, Pamplona, Spain;bDepartment of Clinical Microbiology, Clínica Universidad de Navarra, Pamplona, Spain;cPublic Health Institute of Navarre, Pamplona, Spain;dDepartment of Radiology, Clínica Universidad de Navarra, Pamplona, Spain
Abstract:
The aim of this study was to analyse the effectiveness of teicoplanin versus vancomycin lock therapy in the treatment of coagulase-negative staphylococci (CoNS) venous access port-related bloodstream infection (BSI). The study included 44 consecutive patients during a 36-month prospective case-series study. The primary endpoint was failure to cure. Treatment was successful in 39 patients. At the end of the study, the cumulative port survival rate was 100% in the teicoplanin lock group compared with 77% in the vancomycin lock group (P = 0.06). In the Cox regression analysis, fever beyond 48 h of treatment was a significant predictor of treatment failure (P = 0.02). Use of vancomycin or teicoplanin locks had an effectiveness of 88.6% in the treatment of CoNS port-related BSI. Teicoplanin locks reduced the failure rate from 18.5% to 0% compared with vancomycin locks. The presence of fever after beginning antimicrobial lock therapy was associated with treatment failure.
Keywords:Catheter-related infection   Bacteraemia   Teicoplanin   Biofilms
本文献已被 ScienceDirect 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号