路易斯寡糖在口腔黏膜鳞状细胞癌中的表达及其与颈淋巴结转移的关系

目的　探讨内皮细胞选择素(E-selectin)及其配体路易斯寡糖[sialyl Lewis(a)]在口腔黏膜鳞状细胞癌颈淋巴结转移机制中所起的作用。方法　应用免疫组织化学方法检测口腔鳞癌颈清扫术后标本38例E-Selectin及 sialyl Lewis(a)的表达情况,并与颈淋巴结转移发生进行统计学分析。结果　在口腔癌原发灶组织中sialyl Lewis(a) 在颈淋巴结转移组的表达率为79%(15/19),高于无转移组(21%,4/19),两组间比较有显著性差异(P<0·01),E-Se- lectin表达在两组间无显著性差异(P>0·05)。结论　口腔鳞癌细胞sialyl Lewis(a)的表达与颈淋巴结转移可能有关,似可作为口腔癌颈淋巴结转移的预测指标。

Immunohistochemical Study of Sialyl Lewis(a) Antigen in Oral Squamous Cell Carcinoma: The Association of Sialyl Lewis(a) Expression with Local Lymph Metastasis

Objective The purpose of this study was to screen sialyl Lewis(a)(sLe(a)) in the tumors of patients with oral squamous cell carcinoma (OSCC) and to explore the association of sialyl Lewis(a) expression with local lymph node metastasis.Methods Specimen from 38 patients with primary OSCC were obtained and analyzed by immunohistochemical methods.Results The expression of sLe(a) protein, but not E-selectin, of OSCCs significantly correlated to the local lymph node metastasis. sLe(a) was expressed in 79%(15/19) of the metastastic cases compared with 21% (4/19)of the non-metastasis ones, indicated the association of sLe(a) expression with the local lymph involvement.Conclusion High expression of sLe(a) in OSCC may be related to the metastasis of cervical lymph nodes and it seems useful in predicting poor prognosis in OSCC.