| 3种内服液体制剂中羟苯甲酯和羟苯乙酯的含量测定 |
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| 引用本文： | 朱全刚,胡晋红,孙华君,张莉. 3种内服液体制剂中羟苯甲酯和羟苯乙酯的含量测定[J]. 中国药房, 2002, 13(9): 553-554 |
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| 作者姓名： | 朱全刚 胡晋红 孙华君 张莉 |
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| 作者单位： | 第二军医大学长海医院药学部,上海市200433 |
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| 摘 要： | 目的 :建立内服液体制剂中羟苯甲酯和羟苯乙酯的反相高效液相色谱测定方法。方法 :色谱柱 :Nova -ParkC18 柱(3 9mm×150mm ,5μm) ;流动相 :乙腈 -水 (25∶75) ;流速 :1ml/min ;检测波长 :254nm ;灵敏度 :0 01AUFS。结果 :羟苯甲酯浓度在0 4412～13 2360μg/ml范围内线性关系良好 (r=0 9999) ;羟苯乙酯浓度在0 6672～20 0160μg/ml范围内线性关系良好(r=0 9998)。结论 :该方法简便、快速、准确 ,可用于医院制剂中防腐剂的检测。
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| 关 键 词： | 羟苯甲酯 羟苯乙酯 反相高效液相色谱法 |
| 文章编号： | 1001-0408(2002)09-0553-02 |
| 修稿时间： | 2001-08-27 |
Determination of Methyl Hydroxybenzoate and Ethyl Hydroxybenzoate in Three Oral Liquid Preparations |
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| ZHU Quangang,HU Jinhong,SUN Huajun,ZHANG Li. Determination of Methyl Hydroxybenzoate and Ethyl Hydroxybenzoate in Three Oral Liquid Preparations[J]. China Pharmacy, 2002, 13(9): 553-554 |
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| Authors: | ZHU Quangang HU Jinhong SUN Huajun ZHANG Li |
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| Abstract: | OBJECTIVE:To establish the RP-HPLC method for determination of methyl hydroxybenzoate and ethyl hydroxybenzoate in oral liquid preparations METHODS:The Nova-Park C18 column(3 9mm×150mm,5μm)was used The mobile phase consisted of acetonitrile-water(25∶75)at a flow rate of 1ml/min,the detection wavelength was set at 254nm and the sensitivity was set at 0 01 AUFS RESULTS:The linear ranges of methyl hydroxybenzoate and ethyl hydroxybenzoate were 0 4 412～13 2 360μg/ml(r=0 9 999) and 0 6 672～20 0 160μg/ml(r=0 9 998)respectively CONCLUSION:The method is simple,rapid and accurate It can be used to detect antiseptics in hospital preparations |
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| Keywords: | methyl hydroxybenzoate ethyl hydroxybenzoate RP-HPLC |
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