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| CTLA4Ig基因修饰BMSCs对异种胰岛移植排斥反应的影响 | |
| 引用本文： | 张剑,纳宁,姜楠,汪国营,李华,汪根树,杨扬,陈规划. CTLA4Ig基因修饰BMSCs对异种胰岛移植排斥反应的影响[J]. 解剖学研究, 2011, 33(5): 363-366 |
| 作者姓名： | 张剑 纳宁 姜楠 汪国营 李华 汪根树 杨扬 陈规划 |
| 作者单位： | 中山大学附属第三医院器官移植科,广东 广州,510630 |
| 基金项目： | 国家自然科学基金(81070382); 广东省科技计划资助项目(2008B030301050) |
| 摘 要： | 目的 探讨细胞毒性T淋巴细胞相关抗原4免疫球蛋白( CTLA4Ig)基因修饰骨髓间充质干细胞(BMSCs)在异种胰岛移植排斥反应中的作用.方法 构建携带CTLA4Ig基因的重组腺病毒载体,用其感染BMSCs并和人胰岛细胞移植到糖尿病大鼠肾包膜下,建立人-大鼠异种胰岛移植模型.观察胰岛移植后糖尿病大鼠血糖变化、生存情况以... |
| 关 键 词： | 胰岛移植 糖尿病 骨髓间充质干细胞 细胞毒箼T淋巴细胞相关抗原免疫球蛋白 |
Effects of CTLA4Ig modified bone marrow mesenchymal stem cells on the rejection of rat islet xenografts |
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| ZHANG Jian , NA Ning , JIANG Nan , WANG Guo-ying , LI Hua , WANG Gen-shu , YANG Yang , CHEN Gui-hua. Effects of CTLA4Ig modified bone marrow mesenchymal stem cells on the rejection of rat islet xenografts[J]. Anatomy Research, 2011, 33(5): 363-366 | |
| Authors: | ZHANG Jian NA Ning JIANG Nan WANG Guo-ying LI Hua WANG Gen-shu YANG Yang CHEN Gui-hua |
| Affiliation: | ZHANG Jian,NA Ning,JIANG Nan,WANG Guo-ying,LI Hua,WANG Gen-shu,YANG Yang,CHEN Gui-hua.Organ Transplantation Center,the Third Affiliated Hospital,Sun Yat-sen University,Guangzhou 510630,China |
| Abstract: | Objective To study the effects of cytotoxic Tlymphocyte associated antigen 4 immunoglobulin(CTLA4Ig) modified bone marrow mesenchymal stem cells(BMSCs) on the rejection of rat islet xenografts.Methods The recombinant adenoviruses containing CTLA4Ig gene was constructed and BMSCs were infected with the recombinant adenoviruses.Human islets and infected BMSCs were transplanted under the left kidney capsule of diabetic rats.The blood sugar of transplantation rats was measured and the survival of transplantatio... |
| Keywords: | Islet xenografts Diabetes mellitus Bone marrow mesen chymal stem cells CTLA4Ig |
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