Massive subcutaneous fat necrosis after extravasation of intravenous infusion of fat emulsion |
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| Affiliation: | 1. Department of Microbiology, Henri Mondor University Hospital, Assitance Publique-Hôpitaux de Paris (APHP), University Paris-Est Créteil (UPEC), Créteil, France;2. Department of Pharmacology, Henri Mondor University Hospital, Assitance Publique-Hôpitaux de Paris (APHP), University Paris-Est Créteil (UPEC), Créteil, France;3. Department of Anesthesia and Surgical Intensive Care, Henri Mondor University Hospital of Paris, Paris XII School of Medicine, Créteil, France;4. Groupe de Recherche Clinique IMPACT, Institut Mondor de la Recherche Biomédicale, Université Paris-Est Créteil, Créteil, France;1. Department of Surgery, Yale School of Medicine, New Haven, Connecticut;2. Department of Medicine, Yale School of Medicine, New Haven, Connecticut;3. Department of Pharmacy, Yale-New Haven Hospital, New Haven, Connecticut;4. Department of Pathology, Yale School of Medicine, New Haven, Connecticut;1. Department of Intensive Care, Erasme Hospital, Université Libre de Bruxelles (ULB), Brussels, Belgium;2. Department of Emergency Care and Services, Helsinki University Hospital and University of Helsinki, Finland;3. Critical Care and Anaesthesiology Research Group, Stavanger University Hospital, Stavanger, Norway;4. Department of Clinical Medicine, University of Bergen, Bergen, Norway;5. Department of Anaesthesiology and Intensive Care, Aarhus University Hospital, Aarhus, Denmark;6. Research Center for Emergency Medicine, Department of Emergency Medicine and Department of Clinical Medicine, Aarhus University Hospital and Aarhus University, Denmark;7. Department of Anesthesiology and Intensive Care Medicine, Aarhus University Hospital and Aarhus University, Denmark;8. Department of Internal Medicine, Nephrology and Intensive Care, Charité-Universitätsmedizin Berlin, Berlin, Germany;9. Department of Cardiology, The Heart Center, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark;10. Division of Perioperative Services, Intensive Care Medicine and Pain Management, Turku University Hospital, University of Turku, Turku, Finland;11. Department of Anesthesiology and Intensive Care Medicine, Aalborg University Hospital, and Clinical Institute, Aalborg University, Aalborg, Denmark;12. Department of Neurology, Helsinki University Hospital and University of Helsinki, Finland;1. Biogen, Cambridge, MA, USA;2. Department of Medicine, Imperial College London, London, UK;3. Vall d''Hebron Research Institute, Barcelona, Spain;4. Institute of Biomedicine of Seville Stroke Programme, Seville, Spain;5. Dell Medical School, University of Texas, Austin, TX, USA;6. Department of Neurology, Massachusetts General Hospital, Boston, MA, USA;7. Harborview Medical Centre, University of Washington, Seattle, WA, USA;8. Stanford University Medical Center, Stanford Stroke Center, Stanford, CA, USA;9. Department of Neurology, Columbia University, New York, NY, USA |
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| Abstract: | The recognized usefulness of intravenously administered fat emulsion is not negated by the possibility that extravasation may lead to subcutaneous fat necrosis. With proper administration of the emulsion extravasation will not occur. Subcutaneous extravasation of intravenously administered fat emulsion is not an innocuous occurrence, and may lead to extensive subcutaneous infection and fat necrosis. Our experience suggests that such extravasations may be easily mistaken for local thrombophlebitis or cellulitis. Incisions into the involved area and debridement of necrotic fat tissue should be carried out as soon as the lesion is recognized. |
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