The stability of the drug metabolising enzymes of liver microsomal preparations |
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| Affiliation: | 1. Faculty of Psychology, Southwest University, Chongqing 400715, China;2. College of International Studies, Southwest University, Chongqing 400715, China;3. School of Foreign Languages, Southwest University of Political Science and Law, Chongqing 401120, China;4. Key Laboratory of Cognition and Personality (SWU), MoE, Chongqing 400715, China;1. Neurology Department, The First Affiliated Hospital of Soochow University, Suzhou, China;2. Neurology Department, Yancheng Third People''s Hospital, Yancheng, Jiangsu, China;1. Department of Dentistry, MacKay Memorial Hospital, Taipei, Taiwan;2. Department of Medicine, MacKay Medical College, New Taipei City, Taiwan;3. Department of Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan;4. Department of Oral and Maxillofacial Surgery, MacKay Memorial Hospital, Taipei, Taiwan;5. Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan;6. Graduate Institute of Oral Biology, School of Dentistry, National Taiwan University, Taipei, Taiwan;1. Department of Family Medicine, Taipei Veterans General Hospital, Taipei, Taiwan;2. Department of Medicine, Taipei Veterans General Hospital Yuli Branch, No.91, Xinxing St., Yuli Township, Hualien County, 98142, Taiwan;3. Emergency Department, Yuli Tzu Chi General Hospital, Hualien, Taiwan;4. Department of Family Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan;5. Department of Public Finance, National Chengchi University, Taipei, Taiwan;6. Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei, Taiwan;7. Department of Obstetrics and Gynecology, School of Medicine, National Yang-Ming University, Taipei, Taiwan |
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| Abstract: | The stability of the drug metabolising enzymes of various preparations of rat liver microsomes has been investigated.Four reactions have been studied: (1) the N-demethylation of morphine, (2) the N-demethylation of codeine, (3) the O-demethylation of codeine and (4) the hydroxylation of diethyl tryptamine.The rates of all these reactions are influenced by temperature and an absolute requirement for oxygen and the enzyme activity is linear only over a 30 minute period when the incubation mixture is shaken in air at 37.5 °C.The causes of the instability of these enzyme systems are discussed. |
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