Loss of Heterozygosity at <Emphasis Type="Italic">BRCA1</Emphasis> Locus Is Significantly Associated with Aggressiveness and Poor Prognosis in Breast Cancer期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Loss of Heterozygosity at BRCA1 Locus Is Significantly Associated with Aggressiveness and Poor Prognosis in Breast Cancer

Authors:	Satoko Okada Eriko Tokunaga Hiroyuki Kitao Sayuri Akiyoshi Nami Yamashita Hiroshi Saeki Eiji Oki Masaru Morita Yoshihiro Kakeji Yoshihiko Maehara

Affiliation:	(1) Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan;(2) Department of Molecular Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan;

Abstract:	Background BRCA1 and BRCA2 are two major tumor suppressor genes for hereditary breast and ovarian cancer. In sporadic breast cancer, although somatic mutations of these genes are rare, loss of heterozygosity (LOH) at BRCA1 and BRCA2 loci is common.

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