A novel full-length isoform of murine <Emphasis Type="Italic">pregnancy-specific glycoprotein 16</Emphasis> (<Emphasis Type="Italic">psg16</Emphasis>) is expressed in the brain but does not mediate murine coronavirus (MHV) entry期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

A novel full-length isoform of murine pregnancy-specific glycoprotein 16 (psg16) is expressed in the brain but does not mediate murine coronavirus (MHV) entry

Authors:	Judith?M.?Phillips,I-Ting?Kuo,Chelsea?Richardson,Susan?R.?Weiss mailto:weisssr@upenn.edu" title=" weisssr@upenn.edu" itemprop=" email" data-track=" click" data-track-action=" Email author" data-track-label=" " >Email author

Affiliation:	Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, 203A Johnson Pavilion, 3610 Hamilton Walk, Philadelphia, PA 19104-6076, USA.

Abstract:	The mouse pregnancy-specific glycoprotein 16 (PSG16) has been reported to be an alternative receptor for mouse hepatitis virus (MHV), some strains of which cause encephalitis in mice lacking the canonical receptor CEACAM1a. The known isoforms of PSG16 are N-terminally truncated relative to other PSG family proteins and are expressed in neurons as well as in the placenta. We have cloned a novel full-length isoform of psg16 that is also expressed in the brain, placenta, and retina but, like the truncated form, lacks MHV receptor activity when expressed on 293T cells, suggesting that PSG16 does not mediate CEACAM1a-independent spread of MHV.

Keywords:
本文献已被 PubMed SpringerLink 等数据库收录！