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| COPD大鼠模型海马组织代谢研究 | |
| 引用本文： | 凌学锋,林勇,孙思庆,张蔷. COPD大鼠模型海马组织代谢研究[J]. 东南大学学报(医学版), 2011, 30(5): 732-736 |
| 作者姓名： | 凌学锋 林勇 孙思庆 张蔷 |
| 作者单位： | 1. 东南大学,医学院,江苏,南京,210009 2. 东南大学附属中大医院,呼吸科,江苏,南京,210009 |
| 摘 要： | 目的:探讨慢性阻塞性肺疾病(COPD)并发慢性脑损害的可能分子机制。方法:将24只大鼠随机分为正常对照组、单纯脂多糖组、单纯吸烟组、COPD模型组。采用被动吸烟联合气管内注射脂多糖方法建立COPD大鼠模型,在活体状态下进行高磁场Micro-MRI成像及双侧海马波谱采集,分析大鼠双侧海马氮-乙酰天门冬氨酸复合物(NAA)/肌酸(Cr)、胆碱复合物(Cho)/Cr之值的变化。结果:与正常对照组相比,COPD模型组双侧海马Cho/Cr值显著降低(P<0.05);单纯吸烟组、单纯脂多糖组左侧海马Cho/Cr值也较正常对照组明显低(P<0.05),右侧海马Cho/Cr值无明显差异(P>0.05)。单纯吸烟组、单纯脂多糖组、COPD模型3组间双侧海马Cho/Cr值无明显差异(P>0.05);各组间双侧海马NAA/Cr值无明显差异(P>0.05);各组内左右两侧NAA/Cr、Cho/Cr值无明显差异(P>0.05)。结论:COPD大鼠模型双侧海马Cho/Cr值明显降低,海马组织代谢异常可能是COPD并发慢性脑损害早期病理基础之一。 |
| 关 键 词： | 慢性阻塞性肺疾病 海马 磁共振波谱 大鼠 |
Study of hippocampal metabolism in rats with chronic obstructive pulmonary disease |
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| LING Xue-feng,LIN Yong,SUN Si-qing,ZHANG Qiang. Study of hippocampal metabolism in rats with chronic obstructive pulmonary disease[J]. Journal of Southeast Univ: Medical Sci Ed, 2011, 30(5): 732-736 | |
| Authors: | LING Xue-feng LIN Yong SUN Si-qing ZHANG Qiang |
| Affiliation: | LING Xue-feng1,LIN Yong2,SUN Si-qing2,ZHANG Qiang2(1.Medical College,Southeast University,Nanjing 210009,China,2.Department of Respiratory Medicine,Zhongda Hospital,China) |
| Abstract: | Objective: To explore the possible molecular mechanisms of chronic obstructive pulmonary disease(COPD) with chronic brain damage.Methods: 24 rats were randomly divided to control-group,lipopolysaccharide(LPS)-group,smoking-group,COPD model group.Rats with COPD(model group) was established by passive smoking and intratracheal instillation of LPS,and underwent brain micro-magnetic resonance imaging(MRI) and bilateral hippocampal proton magnetic resonance spectroscopy in vivo.A neurochemical profile consisting... |
| Keywords: | chronic obstructive pulmonary disease hippocampus magnetic resonance spectroscopy rats |
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