普罗布考在高血压大鼠体内药代动力学的研究

目的研究普罗布考在高血压大鼠体内的药代动力学。方法取10只高血压大鼠灌胃给予普罗布考（10mg／kg），于给药后取体内不同时间（0．5，1．0，1．5，2．0，2．5，3．0，4．0，6．0，9．0h）的血样。用高效液相色谱法测定普罗布考的血药浓度，绘制药-时曲线，采用PKS软件计算药代动力学参数。结果普罗布考在高血压大鼠的药．时曲线符合二室模型，其Tmax为（1．917±2．1）h，Cmax分为（25．61±1．0）μg／ml，t1/2为（2．26±0．01）h。结论采用灌胃普罗布考的大鼠体内药动学呈二室模型，分布较快，代谢较慢。

The research on pharmacokinetics of Probucol in Hypertension-rat

Objective To study the pharmacokinetics of probucol in hypertension-rat. Methods 10 hypertensive rats were given probucol by ig ,Blood samples were taken at different time（0. 5 ,1.0 ,1.5 ,2.0 , 2. 5 ,3.0 ,4. 0 ,6. 0 ,9. 0 h） ,The plasma concentrations were determined by HPLC and the plasma concentration-time profiles of probucol were obtained. Results The concentration-time curves of probucol were found to fit a two-compartment open model. The Tmax values of probucol was 1. 917 ± 2. 1 h, the Cmax values was 25.61 ± 1.0μg · ml,the t1/2was2. 26 ± 0. 01 h. Conclusion The pharmacokinetics of probucol is fitted for two compartment model with rapid-distribution and metabolic-slower.