鱼油对胃肠肿瘤病人术后炎性反应及临床预后的影响

目的:探讨鱼油对胃肠肿瘤病人术后炎性反应及临床预后的影响。方法:64例胃肠道肿瘤病人随机分为对照组(32例)和观察组(32例),两组病人均给予PN治疗104.6kJ·kg-1·d-1,观察组加用鱼油。于病人术后d1、d3、d6分别检测中性粒细胞计数(NGC)、血清C反应蛋白(CRP)、血清白介素-1β(IL-1β)、血清白介素-6(IL-6)、血清白介素-10(IL-10)、肿瘤坏死因子-ɑ(TNF-ɑ)的变化。统计两组病人全身炎症反应综合征(SIRS)、术后感染发生率、其他术后并发症发生率、死亡率的变化。结果:术后两组血清IL-1β、CRP、NGC的含量明显变化,观察组指标明显低于对照组(P0.05),观察组SIRS明显低于对照组(P0.05)。结论:鱼油有利于改善胃肠肿瘤病人术后的炎性反应及临床预后。

Impact of postoperative fish oil supplemented on inflammation status and prognosis improve in gastrointestinal cancer patients

Objective ： To investigate the influence of fish oil-based （ω-3） （study group）vs conventional （ω-6）lipid emulsion （control group）on modulating inflammation status and prognosis improve in patients of gastrointestinal tumor. Methods：Sixty-four gastrointestinal cancer volunteers were randomized to receive an ω3 lipid emulsion or a conventional （ω-6）lipid emulsion for 5 days. Blood samples were gained on the morning of day 1, on the morning of day 3 and day 6 after operation respectively to measure IL-1β, IL-10, IL-6, TNF-α and The neutrophilic granulocyte count （NGC）, Serum c-reactive protein （CRP）. The incidence of of two groups of patients with systemic inflammatory response syndrome （SIRS）, postoperative infection, and other postoperative complications and mortality were surveyed. Results ：NGC and C RP, IL-1β of both groups were significantly reduced, and the study group was Significantly lower than control group （P〈0.05）. SIRS in the study group was lower than control group（P〈0.05 ）. Conclusions： Fish oil helps improve postoperative inflammatory response and clinical outcomes for patients with gastrointestinal tumor.