|
|||||
|
|
COMPARISON OF TWO COMMERCIAL TEST KITS FOR QUANTIFICATION OF SERUM CARBOHYDRATE-DEFICIENT TRANSFERRIN |
|
| Authors: | STOWELL, L. I. FAWCETT, J. P. BROOKE, M. ROBINSON, G. M. STANTON, W. R. |
| Affiliation: | 1Institute of Environmental Science and Research Ltd (ESR) Lower Hutt 2School of Pharmacy Dunedin 3Dunedin Multidisciplinary Health and Development Research Unit (DMHDRU), University of Otago Dunedin 4Alcohol and Drug Centre and Kenepuru Hospital, Capital Coast Health Ltd Wellington, New Zealand 5Centre for Health Promotion and Cancer Prevention Research, The University of Queensland Australia |
| Abstract: | Serum levels of carbohydrate-deficient transferrin (CDT) weremeasured in subjects of two independent studies using two differentcommercial kits. The kits measure CDT either as a percentageof total transferrin (AXIS %CDTTM, AXIS Biochemicals AS, Norway),or as the absolute amount (CDTectTM, Pharmacia, Sweden). Ina population of males (mean age 41 years) consisting of alcoholics,heavy, moderate and non-drinkers, a strong correlation was foundbetween AXIS %CDT and CDTect results (r=0.92, n=58, P<0.001).Sensitivity and specificity in detecting chronic alcoholic drinkingof over 60 g/day were 78 and 94% for the AXIS assay, and 83and 88% for the CDTect assay, respectively. In a populationfrom a birth cohort study, consisting of 21-year-old males andfemales with less excessive alcohol consumption, the correlationbetween AXIS %CDT and CDTect CDT was weaker but still statisticallysignificant (r=0.46. n=212, =<0.001). In this population,with specificities >83% in detecting alcohol consumptionlevels of |
| Keywords: | |
| 本文献已被 Oxford 等数据库收录！ | |