| ALOX5AP基因SG13S114A/T多态性与动脉粥样硬化性脑梗死的关系 |
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| 引用本文： | 何颖蕾,朱敏,金笑平,周元林.ALOX5AP基因SG13S114A/T多态性与动脉粥样硬化性脑梗死的关系[J].浙江大学学报(医学版),2009,38(6). |
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| 作者姓名： | 何颖蕾 朱敏 金笑平 周元林 |
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| 作者单位： | 1. 温州医学院,附属台州医院神经内科,浙江,临海,317000
2. 温州医学院,附属台州医院中心实验室,浙江,临海,317000 |
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| 基金项目： | 浙江省医药卫生科学研究基金资助项目 |
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| 摘 要： | 目的:通过检测动脉粥样硬化性脑梗死(ACI)患者ALOX5AP基因SG13S114A/T多态性,探讨ALOX5AP基因SG13S114A/T的多态性与ACI的关系,以及SG13S114A等位是否为ACI的易感基因.方法:用聚合酶链反应限制性片段长度多态性分析法,分析412例确诊的ACI和368例同时与其基础疾病相匹配的非ACI者的ALOX5AP基因SG13S114A/T的多态性,比较两组间该基因多态性的差异.结果:ACI组ALOX5AP基因SG13S114AA基因型频率以及A等位基因均高于对照组,但是两组的差异没有统计学意义(P>0.05).结论:ALOX5AP基因SG13S114A/T的多态性与ACI的发生没有明确的关系,也不能得出该基因的A等位基因为ACI的易感基因的结论.
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| 关 键 词： | 脑梗塞/遗传学 基因型 5-脂氧合酶激活蛋白 动脉粥样硬化性脑梗死 遗传多态性 |
Relationship of polymorphism of SG13S114A/T in ALOX5AP gene with atherosclerotic cerebral infarction |
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| HE Ying-lei,ZHU Min,JIN Xiao-ping,ZHOU Yuan-lin.Relationship of polymorphism of SG13S114A/T in ALOX5AP gene with atherosclerotic cerebral infarction[J].Journal of Zhejiang University(Medical Sciences),2009,38(6). |
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| Authors: | HE Ying-lei ZHU Min JIN Xiao-ping ZHOU Yuan-lin |
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| Abstract: | Objective: To investigate the relationship of the polymorphism of SG13S114A/T in ALOX5AP gene with atherosclerotic cerebral infarction (ACI). Methods: By polymerase chain reaction and restriction fragment length polymorphism,polymorphism of SG13S114A/T in ALOX5AP gene in 412 cases with ACI and 368 non-ACI controls were analyzed. Results: There were no statistically significant differences in the ALOX5AP gene SG13S114 AA genotype and A allele frequencies between ACI group and control group (P>0.05). Conclusion: The results do not support genotype SG13S114 A allele as the risk gene for ACI. |
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| Keywords: | Brain infarction/genet Genotype 5-lipoxygenase activating protein Atherosclerosis cerebral infarction Genetic polymorphism |
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