| 葛根黄酮对大鼠脑缺血再灌注损伤的保护作用 |
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| 引用本文： | 王培源,王海萍,李光武.葛根黄酮对大鼠脑缺血再灌注损伤的保护作用[J].中国中药杂志,2006,31(7):577-579. |
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| 作者姓名： | 王培源 王海萍 李光武 |
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| 作者单位： | 安徽医科大学,神经生物学研究所,安徽,合肥,230032 |
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| 摘 要： | 目的:探讨葛根黄酮对脑缺血再灌注损伤的保护作用。方法:采用大鼠大脑中动脉栓塞模型,研究葛根黄酮对脑缺血再灌注脑组织含水量和脑梗死体积,脑组织中SOD,MDA的影响。结果:葛根黄酮能明显降低大脑中动脉大鼠脑含水量,缩小脑梗死体积,提高SOD的活性,减少缺血再灌大鼠MDA的含量。结论:葛根黄酮具有抗自由基损伤和保护缺血脑组织的作用。
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| 关 键 词： | 葛根黄酮 脑缺血再灌注 自由基 |
| 文章编号： | 1001-5302（2006）07-0577-03 |
| 收稿时间： | 2005-09-12 |
| 修稿时间： | 2005-09-12 |
Protective effect of pueraria flavonoid on the cerebral ischemic reperfusion injury in rats |
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| WANG Pei-yuan;WANG Hai-ping;LI Guang-wu.Protective effect of pueraria flavonoid on the cerebral ischemic reperfusion injury in rats[J].China Journal of Chinese Materia Medica,2006,31(7):577-579. |
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| Authors: | WANG Pei-yuan;WANG Hai-ping;LI Guang-wu |
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| Institution: | Department of Neurobiology, Anhui Medical University, Hefei 230032, China |
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| Abstract: | Objective: To research the protective effect of pueraria flavonoid on the cerebral ischemic reperfusion injury.Method: Using the middle cerebral artery occlusion model(MCAO)in rats,we investigated the influence of pueraria flavonoid on the brain water content,the infarct volume,the activities of SOD,and the content of MDA.Result: Pueraria Flavonoid could obviously reduce the brain water content and the infract volume in MCAO,increase the activities of SOD,and decrease the content of MDA in the cerebral ischemia-reinfusion model of rats. Conclusion: Pueraria has the function of scavenging free radicals and the protective effect on ischemic brain tissue. |
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| Keywords: | pueraria flavonoid cerebral ischemic reperfusion free radicals |
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