特应性皮炎患者严重程度与免疫偏移的相关性研究

目的探讨特应性皮炎患者病情严重程度与Th1、Th2免疫偏移的相关性,以期对特应性皮炎的治疗提供新的思路。方法收集2006年9月至2011年9月年于我院就诊的特应性皮炎患者80例,收集同期健康志愿者80例最为对照,采用EASI对患者严重程度进行评分;采集患者血液标本,ELISA法检测细胞因子IFN-γ、IL-2、IL-4、IL-5、IL-31的表达。比较特应性皮炎患者与健康志愿者体内不同细胞因子的表达,并对细胞因子与EASI进行相关性分析。结果 AD患者IFN-γ、IL-2等Th1细胞因子的表达均低于健康对照组(P<0.05);而IL-4、IL-5、IL-31等Th2细胞因子的表达均高于健康对照组(P<0.05);AD患者IL-4、IL-5、IL-31的表达与EASI均呈正相关性(P<0.05)。结论 AD患者存在不同程度的Th1/Th2免疫偏移,纠正此免疫偏移状态,有望成为AD治疗的新思路。

Correlation Research of Atopic Dermatitis Severity in Patients with Immune Deviation

Objective To investigate patients with atopic dermatitis severity and Th1,Th2 immune changes,with a view to the treatment of atopic dermatitis with new ideas.Methods Collected from 2006 September-2011 year in September in our hospital in patients with atopic dermatitis in 80 cases,collected on 80 healthy volunteers as controls,using EASI in patients with severity score;collecting blood specimen,ELISA assay for the detection of cytokines IFN-γ,IL-2,IL-4,IL-5,IL-31 expression.Comparison of patients with atopic dermatitis and healthy volunteers of different cytokine expression,and cytokine and EASI correlation analysis.Results In patients with AD,IFN-γ,IL-2 and Th1 cytokine expression were lower than those of healthy controls（P0.05）;IL-4,IL-5,IL-31 and Th2 cytokine expression were higher than the control group（P0.05）;IL-4,IL-5,AD in patients with IL-31 expression and EASI were positively correlated（P0.05）.Conclusion AD patients have different degree of Th1/Th2 immune deviation,correction of the immune deviation state,is expected to become the AD treatment of new ideas.