Abstract: | The involvement of endogenous tachykinins in the airway actions of leukotriene C 4 (LTC 4) was studied. LTC 4 (0.5 μg·kg 1 , iv) increased intrapulmonary pressure (IPP) and extravasation of Evans blue in the airways in guinea pigs. CP 96345 {(2S,3S) cis 2 (diphenylmethyl) N (2 methoxyphenyl) methyl] 1 azabicyclooctane 3 amine}, a NK 1 tachykinin receptor antagonist (1 mg·kg 1 , iv) attenuated LTC 4 induced increase of Evans blue extravasation in the airways, and SR 48968 {(S) N methyl N 4 (4 acetylamino 4 phenylpiperidino) 2 (3,4 dichloro phenyl) butyl] benzamide}, a NK 2 receptor antagonist (1 mg·kg 1 , iv) inhibited increase in IPP, respectively. ONO 1078 (0.03 mg·kg 1 , iv), a leukotriene antagonist, decreased both responses. The results indicate that endogenous tachykinins potentiate the responses of LTC 4 on airways, microvascular leakage mediated by NK 1 receptors, and bronchoconstriction by NK 2 receptors. |