A der(19)t(12;19)(q12;p13.3) in a case of pediatric acute leukemia with unusual immunophenotype |
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| Authors: | Leung Elaine Teshima Ikuko Ye Charles Grant Ron Abdelhaleem Mohamed |
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| Affiliation: | Division of Haematology/Oncology, Department of Paediatrics, Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada. |
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| Abstract: | ![]()
We describe a case of acute leukemia in a child with an unusual immunophenotype and a novel cytogenetic abnormality. The leukemia blasts expressed myeloid, natural killer and B-lineage associated antigens. Cytogenetics showed the presence of a novel unbalanced chromosomal translocation, der(19)t(12;19)(q12;p13.3). The patient achieved and maintained remission with myeloid-directed chemotherapy. The differential diagnosis of the immunophenotype and the potential fusion genes are discussed. |
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