| 人参根总皂甙对热应激小鼠免疫功能保护作用的机制初探 |
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| 引用本文： | 吴英良,程秀娟,袁文学,卫小红.人参根总皂甙对热应激小鼠免疫功能保护作用的机制初探[J].中国药理学通报,1993,9(5):379-381. |
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| 作者姓名： | 吴英良 程秀娟 袁文学 卫小红 |
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| 作者单位： | 沈阳药学院生理教研室 110015
(吴英良，程秀娟)，辽宁省药物研究所 沈阳110015
(袁文学)，沈阳药学院生理教研室 110015(卫小红) |
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| 摘 要： | 小鼠在45℃高温环境15 min.末梢血T淋巴细胞百分数和淋巴细胞占白细胞百分数均下降.血清皮质酮升高。应激前15 min lP人参根总皂甙(GRS)50、100 mg·kg~(-1)可防止末梢血T淋巴细胞百分数的降低,但不能抑制血清皮质酮的升高。GRS50mg·kg~(-1)ip可防止末梢血中淋巴细胞占白细胞百分数的降低。GRS50 mg·kg~(-1)、利血平0.5 mg·kg~(-1)或水杨酸毒扁豆碱0.3 mg·kg~(-1)ip均可消除热应激对小鼠迟发超敏反应的抑制作用。
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| 关 键 词： | 人参皂甙 热应激 免疫功能 神经免疫 调节 皮质酮 利血平 毒扁豆碱 |
The mechanisms of protective effects of ginseng root saponins on immunity in heat-stressed mice |
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| WU Ying-Liang,CHENG Xiu-Juan,YUAN Wen-Xue,WEI Xiao-Hong.The mechanisms of protective effects of ginseng root saponins on immunity in heat-stressed mice[J].Chinese Pharmacological Bulletin,1993,9(5):379-381. |
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| Authors: | WU Ying-Liang CHENG Xiu-Juan YUAN Wen-Xue WEI Xiao-Hong |
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| Abstract: | The peripheral blood T- lymphocyte percentage, lympocyte percentage in white blood cell (WBC) of mice in heat environment (45C, 15 min) were diminished, and serum corticosterone increased. Ginseng root saponins (GRS) 50, 100 mg/kg were administered ip at 15 min before the heat-stress, the suppression of peripheral blood T-lymphocyte percentage were prevented, but could not inhibit the increase of
serum corticosterone. GRS 50mgμkg-1ip could inhibit the redution of peripheral lymphocyte percentage. GRS 50mg·kg-1 ,reserpine 0.5mg· kg-1or physostigmine salicylate 0.3 mg·kg-1ip abolished the inhibiting effect of heat-stress on DTH reaction in mice. |
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| Keywords: | ginseng saponins heat-stress immunity neuroimmunomodulation corticosterone reserpine physostigmine salicylate |
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