| 不同厂家丹参注射液物质基础“组分结构”分析及质量比较研究 |
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| 引用本文： | 韩秀娟,封亮,张多多,贾晓斌.不同厂家丹参注射液物质基础“组分结构”分析及质量比较研究[J].中国中药杂志,2016,41(3):427-432. |
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| 作者姓名： | 韩秀娟 封亮 张多多 贾晓斌 |
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| 作者单位： | 南京中医药大学附属中西医结合医院, 江苏南京 210028,江苏省中医药研究院国家中医药管理局中药释药系统重点研究室, 江苏南京 210028,江苏省中医药研究院国家中医药管理局中药释药系统重点研究室, 江苏南京 210028,南京中医药大学附属中西医结合医院, 江苏南京 210028 |
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| 基金项目： | 国家自然科学基金项目(81202906);江苏省自然科学基金项目(BK2012491);江苏省中医药领军人才项目(2006) |
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| 摘 要： | 对10个不同厂家的丹参注射液指纹图谱进行相似性分析,采用高效液相色谱法(HPLC)同时测定丹参注射液中丹参素、原儿茶酸、原儿茶醛、咖啡酸、异阿魏酸、紫草酸、迷迭香酸、丹酚酸B、丹酚酸A、丹酚酸C 10种酚酸类成分,并利用F检验考察10个厂家丹参注射液酚酸类成分相互间的显著性差异程度。结果表明10个厂家丹参注射液的指纹图谱相似度均在0.9以上,不同厂家10种酚酸类成分的质量分数差异较大,通过显著性差异分析丹参注射液酚酸组分中有效成分的质量分数及其配比,发现存在显著性差异,说明市场上丹参注射液疗效参差不齐,其结构配比存在显著性差异。
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| 关 键 词： | 丹参注射液 酚酸类组分 HPLC |
| 收稿时间： | 2015/9/15 0:00:00 |
Quality comparison andstructural characteristics of material basic composition of Danshen injection from different manufacturers |
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| HAN Xiu-juan,FENG Liang,ZHANG Duo-duo and JIA Xiao-bin.Quality comparison andstructural characteristics of material basic composition of Danshen injection from different manufacturers[J].China Journal of Chinese Materia Medica,2016,41(3):427-432. |
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| Authors: | HAN Xiu-juan FENG Liang ZHANG Duo-duo and JIA Xiao-bin |
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| Institution: | Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028, China,Key Laboratory of New Drug Delivery Systems of Chinese Materia Medica, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China,Key Laboratory of New Drug Delivery Systems of Chinese Materia Medica, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China and Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028, China |
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| Abstract: | HPLC was used to analyze the chromatographic fingerprints and determine the contents of tanshinol, protocatechuic acid, protocatechuic aldehyde, caffeic acid, isoferulic acid, lithospermic acid, rosmarinic acid, salvianolic acid B, salvianolic acid A, and salvianolic acid C in Danshen injection from 10 different manufacturers. The significant differences of phenolic compounds in Danshen injection from ten manufacturers were investigated by using F test. The results showed that the similarity degree of Danshen injection from ten manufacturers was above 0.9 and there was significant difference in mass fraction of phenolic compounds between the samples from different manufacturers. The analysis of mass fraction of effective phenolic components and their structural ratios in Danshen injection from the different manufacturers showed significant differences, indicating that the Danshen injection available in market had different curative effects and with significant differences in structural ratios. |
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| Keywords: | Danshen injection phenolic components HPLC |
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