Clinico-endoscopic data and the status of local immunity in intestinal lesions in patients with periodic disease]

Clinicoendoscopic and immunological evaluation of periodic disease patients shows that the disease-related inflammation of the colon is pathogenetically coupled with secretory IgA hypoproduction and abnormal intestinal eubiotic microflora. These facts should be allowed for when making differential diagnosis between periodic disease and gastrointestinal inflammations.