子宫内膜异位患者TGF-β、VEGF和ICAM-1水平及与临床分期关系

目的:观察子宫内膜异位症(EMS)患者纤维化因子转化生长因子-β(TGF-β)、血管内皮生长因子(VEGF)和细胞间黏附分子-1(ICAM-1)水平,并分析其临床意义。方法:选取2017年2月-2018年8月本院接受治疗的子EMS患者100例为观察组,同期体检健康女性100例为对照组。比较两组及观察组不同临床分期患者TGF-β、VEGF和ICAM-1水平,Pearson相关分析法分析观察组TGF-β水平与VEGF、ICAM-1水平的相关性。结果:观察组TGF-β(389.25±12.36pg/ml)、VEGF(178.45±10.02pg/ml)和ICAM-1(186.34±13.15μg/ml)高于对照组(322.16±15.04pg/ml、120.27±8.45pg/ml、104.28±12.93μg/ml(均P<0.001);观察组临床分期Ⅲ-Ⅳ期患者TGF-β、VEGF和ICAM-1水平(411.35±12.95pg/ml、192.92±8.35pg/ml、204.15±15.17μg/ml)高于Ⅰ-Ⅱ期患者(352.94±15.24pg/ml、155.36±7.28pg/ml、168.28±10.02μg/ml)(均P<0.001);TGF-β水平与VEGF、ICAM-1水平正相关(r=0.523、0.489,P<0.05)。结论:子宫内膜异位症患者的TGF-β、VEGF和ICAM-1水平较正常者高,且临床分期高者水平更高。TGF-β与VEGF、ICAM-1水平正相关。

The relationship between the levels of TGF-β,VEGF and ICAM-1 of women with endometriosis and their clinical staging of endometriosis

Objective:To observe the levels of fibroblast growth factor-β(TGF-β),VEGF and ICAM-1 of women with endometriosis,and to analyze their clinical significance.Methods:100 women with endometriosis were enrolled in study group,and 100 healthy women were selected in control group from February to February 2018.The levels of TGF-β,VEGF and ICAM-1 of women were compared between the two groups,and the levels of TGF-β,VEGF and ICAM-1 of women with different clinical staging of endometriosis were observed.Pearson correlation analysis was used to analyze the correlation between TGF-βlevel and the levels of VEGF and ICAM-1 of women in the study group.Results:The levels of TGF-β,VEGF and ICAM-1 of women in the study group were 389.25±12.36pg/ml,178.45±10.02pg/ml,and 186.34±13.15μg/ml,respectively,which were significant higher than those(322.16±15.04pg/ml,120.27±8.45pg/ml,104.28±12.93μg/ml,respectively)of women in the control group.In the study group,the levels of TGF-β,VEGF and ICAM-1 of women with endometriosis clinical stage III-IV were 411.35±12.95pg/ml,192.92±8.35pg/ml,204.15±15.17μg/ml,respectively,which were significant higher than those(352.94±15.24pg/ml,155.36±7.28pg/ml,and 168.28±10.02μg/ml,respectively)of women with endometriosis clinical stage I-II(all P<0.001).TGF-βlevel of women in the study group was positively correlated with their VEGF and ICAM-1 levels(r=0.523,0.489,P<0.05).Conclusion:The levels of TGF-β,VEGF and ICAM-1 of women with endometriosis have increased,and which’s TGF-βlevel is positively correlated with their VEGF and ICAM-1 levels.