冠心病患者sST2和NLR变化及与冠脉病变程度的相关性

目的:探讨冠心病患者血液中可溶性生长刺激表达基因2蛋白(sST2)和中性粒细胞/淋巴细胞比值(NLR)变化及与患者冠脉病变程度的相关性。方法:选取心内科住院患者389例,依CASS诊断标准分为非冠心病组(Non-CHD组,n=72)和冠心病组(CHD组,n=317),CHD组患者根据不同的疾病类型分为非ST段抬高型心肌梗死组(NSTEMI组,n=76)、ST段抬高型心肌梗死组(STEMI组,n=91)、不稳定型心绞痛组(UAP组,n=63)和稳定型心绞痛组(SAP组,n=87);再依据Gensini评分分为轻度组(LD组,Gensini≤30分,n=121)、中度组(MD组,30NSTEMI组>UAP组>SAP组,而NLR水平为STEMI组>UAP组>NSTEMI组>SAP组(P均<0.01)。不同严重程度三个亚组患者血液中sST2和NLR水平呈SD组>MD组>LD组趋势(P均<0.01)。sST2和NLR水平与冠脉病变严重程度呈显著正相关(r=0.77、0.72,P均<0.01)。结论:冠心病患者血液中sST2和NLR水平升高,且其水平与冠脉病变严重程度有关。

The Study of Correlationship between sST2 and NLR and Coronary Lesion Degree in Patients with Coronary Heart Disease

Objective:To investigate of correlationship between soluble growth stimulation expressed gene 2(sST2)and neutrophil-lymphocyte ratio(NLR)and coronary lesion degree in patients with coronary heart disease(CHD).Method:A total of 389 patients with heart pain were respectively divided to Non-CHD group(n=72 cases)and CHD group(n=317 cases),which was continuely divided into Non-ST-elevation myocardial infarction group(NSTEMI group,n=76 cases),ST-elevation myocardial infarction group(STEMI group,n=91 cases),unstableangina pectoris group(UAP group,n=63 cases)and stable angina pectoris group(SAP group,n=87 cases)according to diagnostic criteria come from coronary artery surgery study.And according to Gensini scores estimated by results of percutaneous coronary intervention(PCI),the CHD patients were respectively divided into light degree group(LD group,Gensini≤30,n=121 cases),moderate degree group(MD group,30NSTEMI group>UAP group>SAP group about the level of sST2,and with STEMI group>UAP group>NSTEMI group>SAP group about level of NLR(P of all<0.01).Another the level of sST2 and NLR in patients with different coronary lesion degree were changed form high to low according to SD group,MD group and LD group(P of all<0.01).At last,there was significant positive correlationship between the level of sST2 and NLR and coronary lesion degree in patients with CHD(r=0.77,0.72,P of all<0.01).Conclusion:It was indicated that the levels of sST2 and NLR were significantly increased in patients with CHD,which was attributed to increasing of coronary stenosis degree.