脑小血管病与卒中后抑郁

卒中后抑郁(PSD)作为脑卒中后常见的并发症,对卒中的预后十分不利,因此对其发病机制的研究越来越受到人们的重视.既往影像学研究主要集中在PSD与急性卒中病灶的关系,结论不完全一致.近年来人们发现脑小血管病(SVD)与缺血性卒中密切相关,且很多研究表明SVD为血管性抑郁的重要的影像学表现和诊断标准.但其在PSD发病机制中的作用还不明确.本文主要通过介绍SVD的相关知识及其在PSD发病中的作用,来探讨SVD与PSD的关系.

Small vessel disease and post-stroke depression

Post-stroke depression（PSD） is a frequent neuropsychiatric complication of stroke.More and more researches focus on its pathogenesis.Previous imaging studies which analyzed the relation between PSD and acute stroke lesions made controversial results.Recent studies demonstrated that cerebral small vessel disease（SVD） was closely related to ischemic stroke,and extensive researches indicated that SVD was an important imaging characteristic and diagnostic criteria of vascular depression.However the role of SVD in the pathogenesis of PSD remains uncertain.The aim of this paper was to review the relevant knowledge of SVD and its role in the pathogenesis of PSD to evaluate the relation between SVD and PSD.