| 光纤药物溶出仪过程分析葡萄糖酸锌片溶出度 |
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| 引用本文： | 沈静,王艳,丁海燕.光纤药物溶出仪过程分析葡萄糖酸锌片溶出度[J].中国现代药物应用,2012,6(8):20-21. |
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| 作者姓名： | 沈静 王艳 丁海燕 |
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| 作者单位： | 1. 新疆医科大学第五附属医院药剂科,830011
2. 新疆医科大学药学院 |
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| 基金项目： | 国家科技部“十一五”重大科技支撑计划（项目编号：2006BAK03A16） |
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| 摘 要： | 采用在溶媒中加入锌试剂,实现葡萄糖酸锌片过程监测,建立光纤传感过程分析方法监测葡萄糖酸锌片的溶出度.FODT的标准曲线方程为Y=149.28X+0.74,回归系数r=0.9992.FODT法经与中国药典(Ch.P)2000年版方法对照,提取的参数无显著性差异.该方法能够有效测定固体药物的体外溶出度,获得的数据信息完整,反映了药物在体外的溶出全过程.
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| 关 键 词： | 过程分析 葡萄糖酸锌片 溶出度 |
Fiber-optic process analysis dissolution of zinc gluconate tablet |
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| SHEN Jing
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WANG Yana
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DING Hai-Yana.Fiber-optic process analysis dissolution of zinc gluconate tablet[J].Chinese Journal of Modern Drug Application,2012,6(8):20-21. |
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| Authors: | SHEN Jing WANG Yana DING Hai-Yana |
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| Institution: | a.Department of Pharmacy,The Fifth Teaching Hospital of Xinjiang Medical University,Urumqi 830011,China |
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| Abstract: | A method which can monitor the dissolution rate of zinc gluconate tablets by fiber-optic process analysis was established.It accomplished the on-line monitoring of zinc gluconate tablets by adding zincon to solvent.The average standard curve equation was Y=149.28X ＋0.74,with r of 0.9992.The dissolution parameters obtained by FODT had no significant difference compared with the method in Ch.P 2000（P0.05）.This process analysis is capable of monitoring the real dissolution process of a drug,and in vitro dissolution properties of the tablets are reflected and obtain the total information. |
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| Keywords: | Process analysis Zinc gluconate tablets Dissolution |
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